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Genome editing in zebrafish: a practical overview

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journal contribution
posted on 2016-01-01, 00:00 authored by Robert Sertori, Monique TrengoveMonique Trengove, Faiza Basheer, Alister WardAlister Ward, Clifford LiongueClifford Liongue
Zebrafish is a powerfulmodel for the study of vertebrate development, being amenable to a wide range of genetic and other manipulations to probe themolecular basis of development and its perturbation in disease. Over recent years, genome editing approaches have become increasingly used as an efficient and sophisticated approach to precisely engineer the zebrafish genome, which has further enhanced the utility of this organism. This review provides a practical overview of genome editing and its application in zebrafish research, including alternate strategies for introducing and screening for specific genetic changes.

History

Journal

Briefings in functional genomics

Volume

15

Issue

4

Pagination

322 - 330

Publisher

Oxford University Press

Location

Oxford, Eng.

ISSN

2041-2649

eISSN

2041-2657

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, The Authors