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Genomic analysis of local variation and recent evolution in Plasmodium vivax
journal contribution
posted on 2016-01-01, 00:00 authored by R D Pearson, R Amato, S Auburn, O Miotto, J Almagro-Garcia, C Amaratunga, S Suon, S Mao, R Noviyanti, H Trimarsanto, J Marfurt, N M Anstey, T William, M F Boni, C Dolecek, H T Tran, N J White, P Michon, P Siba, L Tavul, G Harrison, Alyssa BarryAlyssa Barry, I Mueller, M U Ferreira, N Karunaweera, M Randrianarivelojosia, Q Gao, C Hubbart, L Hart, B Jeffery, E Drury, D Mead, M Kekre, S Campino, M Manske, V J Cornelius, B MacInnis, K A Rockett, A Miles, J C Rayner, R M Fairhurst, F Nosten, R N Price, D P Kwiatkowski© 2016 Nature America, Inc. All rights reserved. The widespread distribution and relapsing nature of Plasmodium vivax infection present major challenges for the elimination of malaria. To characterize the genetic diversity of this parasite in individual infections and across the population, we performed deep genome sequencing of >200 clinical samples collected across the Asia-Pacific region and analyzed data on >300,000 SNPs and nine regions of the genome with large copy number variations. Individual infections showed complex patterns of genetic structure, with variation not only in the number of dominant clones but also in their level of relatedness and inbreeding. At the population level, we observed strong signals of recent evolutionary selection both in known drug resistance genes and at new loci, and these varied markedly between geographical locations. These findings demonstrate a dynamic landscape of local evolutionary adaptation in the parasite population and provide a foundation for genomic surveillance to guide effective strategies for control and elimination of P. vivax.
History
Journal
Nature GeneticsVolume
48Issue
8Pagination
959 - 964Publisher
Nature Publishing GroupLocation
London, Eng.Publisher DOI
ISSN
1061-4036eISSN
1546-1718Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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