Deakin University
Browse
lee-gestationalweight-2022.pdf (6.3 MB)

Gestational weight gain is associated with childhood height, weight and BMI in the Peri/Postnatal Epigenetic Twins Study

Download (6.3 MB)
Version 3 2024-06-15, 08:05
Version 2 2024-06-01, 05:14
Version 1 2022-04-01, 08:50
journal contribution
posted on 2024-06-15, 08:05 authored by Debbie AshtreeDebbie Ashtree, DA Osborne, Amelia LeeAmelia Lee, MP Umstad, R Saffery, Jeffrey CraigJeffrey Craig, KJ Scurrah
AbstractMultifetal pregnancies are at risk of adverse maternal, neonatal and long-term health outcomes, and gestational weight gain (GWG) is a potentially modifiable risk factor for several of these. However, studies assessing the associations of GWG with long-term health in twins are rare, and studies which do assess these associations in twins often do not account for gestational age. Since longer gestations are likely to lead to larger GWG and lower risk of adverse outcomes, adjusting for gestational age is necessary to better understand the association of GWG with twin health outcomes. We aimed to explore long-term associations of GWG-for-gestational-age with twin anthropometric measures. The Peri/Postnatal Epigenetic Twins Study (PETS) is a prospective cohort study, which recruited women pregnant with twins from 2007 to 2009. Twins were followed-up at 18 months and 6 years of age. GWG-for-gestational-age z-scores were calculated from pre-pregnancy weight and weight at delivery. We fitted regression models to assess associations of GWG with twin weight, height and BMI at birth, 18 months, and 6 years. Of the 250 women in the PETS, 172 had GWG measured throughout pregnancy. Overall, higher GWG-for-gestational-age z-scores were associated with higher birthweight (β: 0.32 z-scores, 95% Confidence Interval (95% CI): 0.19, 0.45), BMI (β: 0.29 z-scores, 95% CI: 0.14, 0.43) and length (β: 0.27 z-scores, 95% CI: 0.09, 0.45). However, these associations were not observed at 18 months or 6 years of age. GWG was associated with twin length, weight and BMI at birth but not during childhood. Further research is needed to determine the long-term effects of GWG on twin health outcomes.

History

Journal

Journal of Developmental Origins of Health and Disease

Volume

13

Article number

PII S2040174422000113

Pagination

757-765

Location

England

Open access

  • Yes

ISSN

2040-1744

eISSN

2040-1752

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

6

Publisher

CAMBRIDGE UNIV PRESS

Usage metrics

    Research Publications

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC