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Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review
journal contribution
posted on 2013-04-01, 00:00 authored by Wolf MarxWolf Marx, Laisa Teleni, Alexandra L McCarthy, Luis Vitetta, Dan McKavanagh, Damien Thomson, Elisabeth IsenringChemotherapy-induced nausea and vomiting (CINV) is a common side-effect of cytotoxic treatment. It continues to affect a significant proportion of patients despite the widespread use of antiemetic medication. In traditional medicine, ginger (Zingiber officinale) has been used to prevent and treat nausea in many cultures for thousands of years. However, its use has not been confirmed in the chemotherapy context. To determine the potential use of ginger as a prophylactic or treatment for CINV, a systematic literature review was conducted. Reviewed studies comprised randomized controlled trials or crossover trials that investigated the anti-CINV effect of ginger as the sole independent variable in chemotherapy patients. Seven studies met the inclusion criteria. All studies were assessed on methodological quality and their limitations were identified. Studies were mixed in their support of ginger as an anti-CINV treatment in patients receiving chemotherapy, with three demonstrating a positive effect, two in favor but with caveats, and two showing no effect on measures of CINV. Future studies are required to address the limitations identified before clinical use can be recommended.
History
Journal
Nutrition reviewsVolume
71Issue
4Pagination
245 - 254Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
ISSN
0029-6643eISSN
1753-4887Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2013, International Life Sciences InstituteUsage metrics
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No categories selectedKeywords
AntiemeticsAntineoplastic AgentsGingerNauseaNeoplasmsPlant ExtractsRandomized Controlled Trials as TopicTreatment OutcomeVomitingchemotherapyCINVchemotherapy regimenScience & TechnologyLife Sciences & BiomedicineNutrition & DieteticsQUALITY-OF-LIFESUPEROXIDE-ANIONPROOXIDANTPREVENTIONMOTILITYEFFICACYOUTCOMESCOMPLEXPLACEBOTRIAL
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