Deakin University
Browse

File(s) under embargo

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Version 2 2024-06-19, 22:46
Version 1 2023-11-27, 04:53
journal contribution
posted on 2024-06-19, 22:46 authored by B Zhou, KE Sheffer, JE Bennett, EW Gregg, G Danaei, RK Singleton, JE Shaw, A Mishra, VPF Lhoste, RM Carrillo-Larco, AP Kengne, NH Phelps, RA Heap, AW Rayner, GA Stevens, CJ Paciorek, LM Riley, MJ Cowan, S Savin, S Vander Hoorn, Y Lu, ME Pavkov, G Imperatore, CA Aguilar-Salinas, NA Ahmad, RM Anjana, K Davletov, F Farzadfar, C González-Villalpando, YH Khang, HC Kim, T Laatikainen, A Laxmaiah, JCN Mbanya, KMV Narayan, A Ramachandran, AN Wade, T Zdrojewski, M Abbasi-Kangevari, HFA Rahim, NM Abu-Rmeileh, S Adambekov, RJ Adams, W Aekplakorn, IA Agdeppa, J Aghazadeh-Attari, C Agyemang, A Ahmadi, N Ahmadi, SH Ahmed, K Ajlouni, H Al-Hinai, B Al-Lahou, JA Al-Lawati, DA Asfoor, NM Al Qaoud, M Alarouj, F AlBuhairan, S AlDhukair, MA Aldwairji, MM Ali, F Alinezhad, A Alkandari, HF Alomirah, E Aly, DN Amarapurkar, LB Andersen, SA Anderssen, DS Andrade, A Ansari-Moghaddam, H Aounallah-Skhiri, T Aris, N Arlappa, KK Aryal, FK Assah, B Assembekov, J Auvinen, M Avdičová, K Azad, M Azimi-Nezhad, F Azizi, F Bacopoulou, N Balakrishna, M Bamoshmoosh, M Banach, P Bandosz, JR Banegas, CM Barbagallo, A Barceló, M Baretić, L Barrera, A Basit, AM Batieha, AP Batista, LA Baur, A Belavendra, H Ben Romdhane, M Benet, S Berkinbayev
AbstractFasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.

History

Journal

Nature Medicine

Volume

29

Pagination

2885-2901

Location

United States

ISSN

1078-8956

eISSN

1546-170X

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

11

Publisher

NATURE PORTFOLIO