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Glucose metabolism in pregnant sheep when placental growth is restricted

Version 2 2024-06-05, 02:02
Version 1 2019-01-16, 14:56
journal contribution
posted on 2024-06-05, 02:02 authored by Julie OwensJulie Owens, J Falconer, JS Robinson
The effect of restricting placental growth on glucose metabolism in pregnant sheep in late gestation was determined by primed constant infusions of D-[U-14C]- and D-[2-3H]glucose and antipyrine into fetuses of six control sheep and six sheep from which endometrial caruncles had been removed before pregnancy (caruncle sheep). In the latter, placental and fetal weights were reduced, as was the concentration of glucose in fetal arterial blood. Fetal glucose turnover in caruncle sheep was only 52-59% of that in controls, largely because of lower umbilical loss of glucose back to the placenta (38-39% of control) and lower fetal glucose utilization (61-74% of control). However, fetal glucose utilization on a weight-specific basis was similar in control and caruncle sheep. Significant endogenous glucose production occurred in control and caruncle fetal sheep. Maternal glucose production and partition of glucose between the gravid uterus and other maternal tissues were similar in control and caruncle sheep. In conclusion, when placental and fetal growth are restricted, fetal glucose utilization is maintained by reduced loss of glucose back to the placenta and mother and by maintaining endogenous glucose production.

History

Journal

American journal of physiology: regulatory, integrative and comparative physiology

Volume

257

Pagination

R350-R357

Location

Bethesda, Md.

ISSN

0363-6119

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1989, American Physiological Society

Issue

2

Publisher

American Physiological Society

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