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Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

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journal contribution
posted on 2021-10-26, 00:00 authored by E L Connolly, M Sim, N Travica, Wolf MarxWolf Marx, G Beasy, G S Lynch, C P Bondonno, J R Lewis, J M Hodgson, L C Blekkenhorst
An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including cardiometabolic, neurological, and musculoskeletal conditions, and certain cancers. A possible protective component, glucosinolates, which are phytochemicals found almost exclusively in cruciferous vegetables, have been identified from preclinical and clinical studies. Current research suggests that glucosinolates (and isothiocyanates) act via several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. This review summarizes the current knowledge surrounding cruciferous vegetables and their glucosinolates in relation to the specified health conditions. Although there is evidence that consumption of a high glucosinolate diet is linked with reduced incidence of chronic diseases, future large-scale placebo-controlled human trials including standardized glucosinolate supplements are needed.

History

Journal

Frontiers in Pharmacology

Volume

12

Article number

ARTN 767975

Pagination

1 - 12

Publisher

Frontiers Media SA

Location

Lausanne, Switzerland

ISSN

1663-9812

eISSN

1663-9812

Language

English

Publication classification

C1 Refereed article in a scholarly journal