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Glutathione : a novel treatment target in psychiatry
journal contribution
posted on 2008-07-01, 00:00 authored by Michael BerkMichael Berk, F Ng, Olivia DeanOlivia Dean, Seetal DoddSeetal Dodd, A BushThere is accumulating evidence for oxidative stress mechanisms as common pathophysiological pathways in diverse psychiatric disorders, which offers novel treatment targets in oxidation biology systems. Of these the glutathione system has the most favourable theoretical foundation, given its dominance as the most generic of cellular antioxidants. Clinically, this hypothesis has been supported by several recently published studies that have reported on the efficacy of N-acetylcysteine, a glutathione precursor, in the treatment of various psychiatric disorders. This article outlines the multidimensional evidence that currently exists for oxidative stress mechanisms in psychiatric disorders and specifically discusses glutathione as a promising novel therapeutic target.
History
Journal
Trends in pharmacological sciencesVolume
29Issue
7Pagination
346 - 351Publisher
ElsevierLocation
London, EnglandPublisher DOI
ISSN
0165-6147eISSN
1873-3735Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008, ElsevierUsage metrics
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