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Glycerophospholipid supplementation as a potential intervention for supporting cerebral structure in older adults

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Version 2 2024-06-04, 04:53
Version 1 2018-03-12, 13:58
journal contribution
posted on 2024-06-04, 04:53 authored by JM Reddan, DJ White, Helen MacphersonHelen Macpherson, A Scholey, A Pipingas
Modifying nutritional intake through supplementation may be efficacious for altering the trajectory of cerebral structural decline evident with increasing age. To date, there have been a number of clinical trials in older adults whereby chronic supplementation with B vitamins, omega-3 fatty acids, or resveratrol, has been observed to either slow the rate of decline or repair cerebral tissue. There is also some evidence from animal studies indicating that supplementation with glycerophospholipids (GPL) may benefit cerebral structure, though these effects have not yet been investigated in adult humans. Despite this paucity of research, there are a number of factors predicting poorer cerebral structure in older humans, which GPL supplementation appears to beneficially modify or protect against. These include elevated concentrations of homocysteine, unbalanced activity of reactive oxygen species both increasing the risk of oxidative stress, increased concentrations of pro-inflammatory messengers, as well as poorer cardio- and cerebrovascular function. As such, it is hypothesized that GPL supplementation will support cerebral structure in older adults. These cerebral effects may influence cognitive function. The current review aims to provide a theoretical basis for future clinical trials investigating the effects of GPL supplementation on cerebral structural integrity in older adults.

History

Journal

Frontiers in Aging Neuroscience

Volume

10

Article number

ARTN 49

Location

Switzerland

ISSN

1663-4365

eISSN

1663-4365

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, The Authors

Issue

MAR

Publisher

FRONTIERS MEDIA SA