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Granulocyte colony-stimulating factor and its potential application for skeletal muscle repair and regeneration

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journal contribution
posted on 07.12.2017, 00:00 authored by Craig WrightCraig Wright, Alister WardAlister Ward, Aaron RussellAaron Russell
Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Skeletal muscle damage, including that following strenuous exercise, induces an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair. This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.

History

Journal

Mediators of inflammation

Volume

2017

Article number

7517350

Pagination

1 - 9

Publisher

Hindawi Publishing Corporation

Location

Cairo, Egypt

eISSN

1466-1861

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal