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Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more
journal contribution
posted on 2009-12-01, 00:00 authored by Clifford LiongueClifford Liongue, Craig WrightCraig Wright, Aaron RussellAaron Russell, Alister WardAlister WardThe granulocyte colony-stimulating factor receptor (G-CSFR) plays an important role in the production, survival and activation of neutrophilic granulocytes during both normal and emergency hematopoiesis. The G-CSFR also participates in the development of other myeloid lineages, the mobilization of hematopoietic stem cells and myeloid cell migration. This has lead to several important clinical applications for its ligand, G-CSF. More recently, additional important roles for G-CSFR have emerged outside the hematopoietic system, such as in the protection and repair of a diverse range of tissues, including muscle, liver and neural tissue, providing further scope for developing G-CSF as a therapeutic agent. The G-CSFR has also been implicated in the etiology of disease, with mutations/variants of G-CSFR implicated in neutropenia, myelodysplasia and leukemia. Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
History
Journal
International journal of biochemistry and cell biologyVolume
41Issue
12Pagination
2372 - 2375Publisher
Elsevier Ltd.Location
Amsterdam, The NetherlandsPublisher DOI
ISSN
1357-2725eISSN
1878-5875Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2009, Elsevier Ltd.Usage metrics
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