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Graphene oxide decorated diatom silica particles as new nano-hybrids: Towards smart natural drug microcarriers
journal contribution
posted on 2013-01-01, 00:00 authored by T Kumeria, M Bariana, T Altalhi, M Kurkuri, C T Gibson, Wenrong YangWenrong Yang, D LosicHerein, we demonstrate the fabrication of a novel nano-hybrid material based on diatom silica microparticles from diatomaceous earth (DE) and graphene oxide (GO). Two different approaches for the fabrication of nano-hybrids were used, including covalent coupling of GO sheets onto the diatom surface and electrostatic attachment. Covalent attachment was carried out through a facile amine coupling strategy via activation of carboxyl groups on GO, followed by covalent attachment to amine terminal groups of 3-aminopropyl-triethoxysilane (APTES) functionalized DE particles. Electrostatic attachment of GO (i.e. negatively charged) was carried out on positively charged APTES functionalized DE particles. The GO decorated DE nano-hybrids prepared with both the fabrication processes were extensively characterized by SEM, TEM, FTIR, and Raman spectroscopy to confirm the new chemical composition and structure. The application of the GO-DE nano-hybrid as a smart pH sensitive micro-drug carrier at pH 7.4 and pH 3.5 was demonstrated using a model drug, indomethacin (IMC). Finally, the drug release data were fitted to zero-order and Korsmeyer-Peppas models to understand the mechanism of drug release. This journal is © The Royal Society of Chemistry.
History
Journal
Journal of materials chemistry BVolume
1Issue
45Pagination
6302 - 6311Publisher
Royal Society of ChemistryLocation
Cambridge, Eng.Publisher DOI
ISSN
2050-7518eISSN
2050-750XLanguage
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2013, Royal Society of ChemistryUsage metrics
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