Deakin University
Browse

Gut microbiota differences between healthy older adults and individuals with Parkinson's disease: a systematic review

Version 2 2024-06-04, 04:54
Version 1 2020-04-16, 10:02
journal contribution
posted on 2024-06-04, 04:54 authored by ND Nuzum, A Loughman, Ewa Szymlek-GayEwa Szymlek-Gay, A Hendy, Wei-Peng TeoWei-Peng Teo, Helen MacphersonHelen Macpherson
The ‘Dual Hit’ hypothesis, stating that Parkinson's disease (PD) begins via olfactory pathways and the gut, and the gastrointestinal symptoms PD individuals face, have largely driven the interest of the gut's involvement in PD. Studies have since observed gut microbiota differences between PD groups and controls, with these alterations potentially relating to PD pathophysiology. However, differences in the studies’ methodologies precludes unanimity on the relationships of gut microbiota to PD. Thirteen observational case-control studies investigating gut microbiota in PD and controls were reviewed to assess how microbiota abundance and diversity relates to PD. Nine studies showed butyrate producing gut microbiota had lower abundances in PD compared to controls. Three studies reported α-diversity was higher, with one reporting it was lower, in PD compared to controls. Given most studies show abundance, not diversity, differences of butyrate producing bacteria between groups, we propose abundance differences are more associated with PD than microbiota diversity. As current research is observational, investigating how specific bacteria and their metabolites may alter throughout PD progression is warranted.

History

Journal

Neuroscience and biobehavioral reviews

Volume

112

Pagination

227-241

Location

Amsterdam, The Netherlands

ISSN

0149-7634

eISSN

1873-7528

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Publisher

Elsevier

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC