tan-helicobacterpylorigenetic-2014.pdf (1.13 MB)
Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia
journal contribution
posted on 2014-12-11, 00:00 authored by S P Gunaletchumy, I Seevasant, Mun Hua Tan, Larry CroftLarry Croft, H M Mitchell, K L Goh, M F Loke, J VadiveluHelicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.
History
Journal
Scientific ReportsVolume
4Article number
7431Pagination
1 - 9Publisher
Nature Publishing GroupLocation
London, Eng.Publisher DOI
ISSN
2045-2322eISSN
2045-2322Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2014, The AuthorsUsage metrics
Categories
No categories selectedKeywords
Amino Acid SequenceBacterial Outer Membrane ProteinsFructose-Bisphosphate AldolaseGastritisGenes, BacterialGenetic Association StudiesGenetic VariationHelicobacter InfectionsHelicobacter pyloriHumansMalaysiaMolecular Sequence DataMultilocus Sequence TypingPeptic UlcerPhylogenyStomach NeoplasmsScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsCAGA EPIYA MOTIFGASTRIC-CANCERVARIABLE REGIONINFECTIONGENOMEINTERLEUKIN-8STRAINSCHINAVACAASIA