Deakin University
Browse

Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia

Download (1.13 MB)
Version 2 2024-06-04, 13:29
Version 1 2017-10-24, 16:00
journal contribution
posted on 2024-06-04, 13:29 authored by SP Gunaletchumy, I Seevasant, MH Tan, LJ Croft, HM Mitchell, KL Goh, MF Loke, J Vadivelu
Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.

History

Journal

Scientific Reports

Volume

4

Article number

7431

Pagination

1-9

Location

London, Eng.

Open access

  • Yes

ISSN

2045-2322

eISSN

2045-2322

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2014, The Authors

Publisher

Nature Publishing Group