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Helicobacter pylori ribosomal protein-A2 peptide/ silk fibroin nanofibrous composites as potential wound dressing

Version 2 2024-06-06, 09:48
Version 1 2019-03-14, 12:58
journal contribution
posted on 2024-06-06, 09:48 authored by D Zhang, L Fan, L Ma, J Liu, K Zhou, X Song, M Sun, X Mo, C He, Y Chen, H Wang
Copyright © 2019 American Scientific Publishers All rights reserved. Although different kinds of antibacterial formulas have been explored against bacterial infections, the development of both biocompatible and efficiently antibacterial matrices is still a challenge. In this study, we report a novel HPRP-A2 antimicrobial peptide/silk fibroin (SF) composite nanofibrous matrix fabricated by an all-aqueous electrospinning process (HPRP-A2 is an antibacterial peptide originated from Helicobacter pylori). The HPRP-A2/SF composite nanofibers had a round and smooth morphology. The incorporation of HPRP-A2 had little influence on both the morphology and biocompatibility of the SF nanofibers. Interestingly, the composite nanofibrous matrices showed an impressive antimicrobial activity against both Gram-positive and Gram-negative bacteria. Furthermore, the HPRP-A2/SF composite nanofibers showed excellent performance on accelerating healing of wound according to the data of animal experiment. Considering the facile and all-aqueous process, the HPRP-A2/SF composite nanofibrous matrices could be a promising candidate for antibacterial or wound management applications.

History

Journal

Journal of biomedical nanotechnology

Volume

15

Pagination

507-517

Location

Valencia, Calif.

ISSN

1550-7033

eISSN

1550-7041

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, American Scientific Publishers

Issue

3

Publisher

American Scientific Publishers