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Hemispheric lateralization of topological organization in structural brain networks
journal contribution
posted on 2014-09-01, 00:00 authored by Karen CaeyenberghsKaren Caeyenberghs, A LeemansThe study on structural brain asymmetries in healthy individuals plays an important role in our understanding of the factors that modulate cognitive specialization in the brain. Here, we used fiber tractography to reconstruct the left and right hemispheric networks of a large cohort of 346 healthy participants (20-86 years) and performed a graph theoretical analysis to investigate this brain laterality from a network perspective. Findings revealed that the left hemisphere is significantly more "efficient" than the right hemisphere, whereas the right hemisphere showed higher values of "betweenness centrality" and "small-worldness." In particular, left-hemispheric networks displayed increased nodal efficiency in brain regions related to language and motor actions, whereas the right hemisphere showed an increase in nodal efficiency in brain regions involved in memory and visuospatial attention. In addition, we found that hemispheric networks decrease in efficiency with age. Finally, we observed significant gender differences in measures of global connectivity. By analyzing the structural hemispheric brain networks, we have provided new insights into understanding the neuroanatomical basis of lateralized brain functions. © 2014 Wiley Periodicals, Inc.
History
Journal
Human Brain MappingVolume
35Issue
9Pagination
4944 - 4957Publisher
WileyLocation
London, Eng.Publisher DOI
ISSN
1065-9471eISSN
1097-0193Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
diffusion tensor imaginggraph theoretical analysislateralizationdevelopmentgenderstructural connectomeScience & TechnologyLife Sciences & BiomedicineNeurosciencesNeuroimagingRadiology, Nuclear Medicine & Medical ImagingNeurosciences & NeurologyDIFFUSION-WEIGHTED MRIWHITE-MATTER INTEGRITYSPHERICAL DECONVOLUTIONSMALL-WORLDBEHAVIOR RELATIONSHIPSANATOMICAL NETWORKHIPPOCAMPAL VOLUMEFIBER ORIENTATIONSGENDER-DIFFERENCESHEALTHY-SUBJECTS
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