fraser-hemodynamicand-2020.pdf (563.79 kB)
Hemodynamic and perceptual responses to blood flow-restricted exercise among patients undergoing dialysis
journal contribution
posted on 2020-03-01, 00:00 authored by Matthew Clarkson, C Brumby, Steve FraserSteve Fraser, L P McMahon, P N Bennett, Stuart WarmingtonStuart WarmingtonEnd-stage kidney disease is associated with reduced exercise capacity, muscle atrophy, and impaired muscle function. While these may be improved with exercise, single modalities of exercise do not traditionally elicit improvements across all required physiological domains. Blood flow-restricted exercise may improve all of these physiological domains with low intensities traditionally considered insufficient for these adaptions. Investigation of this technique appeals, but is yet to be evaluated, in patients undergoing dialysis. With the use of a progressive crossover design, 10 satellite patients undergoing hemodialysis underwent three exercise conditions over 2 wk: two bouts (10 min) of unrestricted cycling during two consecutive hemodialysis sessions (condition 1), two bouts of cycling with blood flow restriction while off hemodialysis on 2 separate days (condition 2), and two bouts of cycling with blood flow restriction during two hemodialysis sessions (condition 3). Outcomes included hemodynamic responses (heart rate and blood pressure) throughout all sessions, participant-perceived exertion and discomfort on a Borg scale, and evaluation of ultrafiltration rates and dialysis adequacy (Kt/V) obtained post hoc. Hemodynamic responses were consistent regardless of condition. Significant increases in heart rate, systolic blood pressure, and mean arterial blood pressure (P < 0.05) were observed postexercise followed by a reduction in blood pressures during the 60-min recovery (12, 5, and 11 mmHg for systolic, diastolic, and mean arterial pressures, respectively). Blood pressures returned to predialysis ranges following the recovery period. Blood flow restriction did not affect ultrafiltration achieved or Kt/V. Hemodynamic safety and tolerability of blood flow restriction during aerobic exercise on hemodialysis is comparable to standard aerobic exercise.
History
Journal
American journal of physiology. Renal physiologyVolume
318Issue
3Pagination
F843 - F850Publisher
American Physiological SocietyLocation
Bethesda, Md.Publisher DOI
Link to full text
ISSN
0363-6127eISSN
1522-1466Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Keywords
Blood flow restrictionBlood pressureEnd-stage kidney diseaseHemodialysisIntradialytic exerciseScience & TechnologyLife Sciences & BiomedicinePhysiologyUrology & NephrologySTAGE RENAL-DISEASEQUALITY-OF-LIFEMUSCLE HYPERTROPHYPHYSICAL FUNCTIONSKELETAL-MUSCLEMAINTENANCE HEMODIALYSISKIDNEY-DISEASEOLDER-ADULTSPRESSURESTRENGTHPhysiology
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