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Hepatic extraction of morphine is impaired in cirrhosis

journal contribution
posted on 2022-11-29, 23:23 authored by Brendan CrottyBrendan Crotty, K J R Watson, P V Desmond, M L Mashford, L J Wood, J Colman, F J Dudley
Using hepatic vein catheterization this study has provided the first direct measurement of morphine hepatic extraction in 8 controls and 8 cirrhotics. The extraction ratio was 0.52 in the control group and was reduced by 25% in the cirrhotics. This reduction is due to impaired enzyme capacity rather than reduced blood flow. The effect of cirrhosis is less than that reported in similar studies of high clearance oxidized drugs and this lends support to the concept that glucuronidation may be relatively spared in cirrhosis. A discrepancy between the systemic clearance and the hepatic clearance provides indirect support for extra-hepatic metabolism of morphine. © 1989 Springer-Verlag.

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Journal

European Journal of Clinical Pharmacology

Volume

36

Pagination

501 - 506

ISSN

0031-6970

eISSN

1432-1041

Publication classification

C1.1 Refereed article in a scholarly journal

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