youssef-heritabilityofoverlapping-2020.pdf (1.15 MB)
Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
journal contribution
posted on 2020-09-01, 00:00 authored by J Tiego, S R Chamberlain, B J Harrison, A Dawson, L Albertella, George YoussefGeorge Youssef, L F Fontenelle, M YücelImpulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A2 = 0.33), modest additive genetic or common environmental effects for obsessiveness (A2 = 0.25; C2 = 0.23), and moderate effects of common environment (C2 = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.
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Journal
Scientific ReportsVolume
10Issue
1Article number
14378Pagination
1 - 17Publisher
Springer Science and Business Media LLCLocation
Berlin, GermanyPublisher DOI
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ISSN
2045-2322eISSN
2045-2322Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2020, The Author(s)Usage metrics
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