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High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men

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journal contribution
posted on 2020-06-01, 00:00 authored by Lewan ParkerLewan Parker, D J Morrison, A C Beti, Katherine Roberts - Thomson, Gunveen KaurGunveen Kaur, Glenn WadleyGlenn Wadley, C S Sha, M A Kesk
Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF), which may contribute to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load would prevent postprandial MBF dysfunction. Ten healthy young men (age, 27 yr [24, 30], mean with lower and upper bounds of the 95% confidence interval; height, 180 cm [174, 185]; weight, 77 kg [70, 84]) ingested a high-glucose (1.1 g/kg glucose) mixed-nutrient meal (10 kcal/kg; 45% carbohydrate, 20% protein, and 35% fat) in the morning after an overnight fast. Femoral arterial blood flow was measured via Doppler ultrasound, and thigh MBF was measured via contrast-enhanced ultrasound, before meal ingestion and 1 h and 2 h postprandially. Blood glucose and plasma insulin were measured at baseline and every 15 min throughout the 2-h postprandial period. Compared with baseline, thigh muscle microvascular blood volume, velocity, and flow were significantly impaired at 60 min postprandial (−25%, −27%, and −46%, respectively; all P < 0.05) and to a greater extent at 120 min postprandial (−37%, −46%, and −64%; all P < 0.01). Heart rate and femoral arterial diameter, blood velocity, and blood flow were significantly increased at 60 min and 120 min postprandial (all P < 0.05). Higher blood glucose area under the curve was correlated with greater MBF dysfunction ( R2 = 0.742; P < 0.001). Ingestion of a high-glucose mixed-nutrient meal impairs MBF in healthy individuals for up to 2 h postprandial

History

Journal

American Journal of Physiology - Endocrinology and Metabolism

Volume

318

Issue

6

Pagination

E1014 - E1021

Publisher

American Physiological Society

Location

Rockville, Md.

ISSN

0193-1849

eISSN

1522-1555

Language

eng

Publication classification

C1 Refereed article in a scholarly journal