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High-performance multifunctional graphene-PLGA fibers: toward biomimetic and conducting 3D scaffolds

Version 2 2024-06-03, 23:24
Version 1 2016-06-02, 10:33
journal contribution
posted on 2016-05-10, 00:00 authored by D Esrafilzadeh, R Jalili, E M Stewart, S H Aboutalebi, Joselito RazalJoselito Razal, S E Moulton, G G Wallace
The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, it is demonstrated that with the aid of rheological insights, optimized formulations of graphene containing spinnable poly(lactic-co-glycolic acid) (PLGA) dopes can be made possible. This helps extend the general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solution-processed graphene into the design process and practical fiber architectural engineering. The as-produced fibers are found to exhibit excellent electrical conductivity and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt%), the conductivity of as-prepared fibers is as high as 150 S m-1 (more than two orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber are enhanced 647- and 59-folds, respectively, through addition of graphene.

History

Journal

Advanced functional materials

Volume

26

Issue

18

Pagination

3105 - 3117

Publisher

Wiley

Location

London, Eng.

ISSN

1616-301X

eISSN

1616-3028

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2016, Wiley-VCH Verlag GmbH & Co. KGaA Weinheim