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High salt diet decreases longevity in the spontaneously hypertensive rat
journal contributionposted on 1988-04-01, 00:00 authored by Robert Di Nicolantonio, M J Silvapulle, S Spargo, T O Morgan
1. Blood pressure, body weight and mortality rate were examined in female spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on a lifelong high (5% NaCl w/w) or low (0.1% NaCl w/w) salt diet. 2. A high salt diet increased mortality and decreased body weight in SHR, but failed to significantly alter blood pressure up to 24 months of age. 3. Hence, a low salt diet does not appear to be a long-term risk factor and may protect the SHR from cardiovascular accidents.
JournalClinical and experimental pharmacology and physiology
Pagination357 - 359
PublisherJohn Wiley & Sons
Publication classificationCN.1 Other journal article