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High salt diet decreases longevity in the spontaneously hypertensive rat

journal contribution
posted on 1988-04-01, 00:00 authored by Robert Di Nicolantonio, M J Silvapulle, S Spargo, T O Morgan
1. Blood pressure, body weight and mortality rate were examined in female spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on a lifelong high (5% NaCl w/w) or low (0.1% NaCl w/w) salt diet. 2. A high salt diet increased mortality and decreased body weight in SHR, but failed to significantly alter blood pressure up to 24 months of age. 3. Hence, a low salt diet does not appear to be a long-term risk factor and may protect the SHR from cardiovascular accidents.

History

Journal

Clinical and experimental pharmacology and physiology

Volume

15

Issue

4

Pagination

357 - 359

Publisher

John Wiley & Sons

Location

Australia

ISSN

0305-1870

Language

eng

Publication classification

CN.1 Other journal article