File(s) under permanent embargo
Higher fish consumption and lower risk of central nervous system demyelination
journal contribution
posted on 2023-04-18, 06:17 authored by LJ Black, Y Zhao, YC Peng, JL Sherriff, RM Lucas, I van der Mei, G Pereira, C Chapman, A Coulthard, K Dear, T Dwyer, T Kilpatrick, R Lucas, T McMichael, MP Pender, AL Ponsonby, B Taylor, P Valery, D WilliamsBackground/Objectives: The evidence for diet as a risk factor for multiple sclerosis (MS) is inconclusive. We examined the associations between fish consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS. Methods: The 2003–2006 Ausimmune Study was a case-control study examining environmental risk factors for FCD, with participants recruited from four regions of Australia and matched on age, sex, and study region. Dietary intake data were collected using a food frequency questionnaire. We used conditional logistic regression models to test associations between fish consumption (total, tinned, grilled, and fried) and risk of FCD (249 cases and 438 controls), adjusting for history of infectious mononucleosis, smoking, serum 25-hydroxyvitamin D concentrations, socio-economic status, omega-3 supplement use, dietary under-reporting, and total energy intake. Results: Higher total fish consumption (per 30 g/day, equivalent to two serves/week) was associated with an 18% reduced risk of FCD (AOR 0.82; 95% CI 0.70, 0.97). While we found no statistically significant associations between grilled and fried fish consumption and risk of FCD, higher tinned fish consumption (per 30 g/day) was associated with a 41% reduced risk of FCD (AOR 0.59; 95% CI 0.39, 0.89). Conclusions: Tinned fish is predominantly oily, whereas grilled and fried fish are likely to be a combination of oily and white types. Oily fish is high in vitamin D and very long chain polyunsaturated omega-3 fatty acids, both of which may be beneficial in relation to MS.
History
Journal
European Journal of Clinical NutritionVolume
74Pagination
818-824Location
EnglandPublisher DOI
ISSN
0954-3007eISSN
1476-5640Language
enPublication classification
C1.1 Refereed article in a scholarly journalIssue
5Publisher
Springer Science and Business Media LLCUsage metrics
Categories
Keywords
AdultAnimalsAustraliaCase-Control StudiesCentral Nervous SystemDemyelinating DiseasesDietFatty Acids, Omega-3FemaleFishesHumansMaleMultiple SclerosisRisk FactorsSeafoodAusimmune Investigator GroupPreventionBrain DisordersNutritionComplementary and Integrative HealthClinical ResearchNeurosciencesNeurodegenerativeNeurologicalHuman Movement and Sports Science not elsewhere classifiedFood Sciences not elsewhere classifiedNutrition and Dietetics not elsewhere classified
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC