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Hormone therapy and risk of non-vertebral fracture : Geelong Osteoporosis Study

journal contribution
posted on 2004-01-01, 00:00 authored by Julie PascoJulie Pasco, Mark KotowiczMark Kotowicz, Margaret Rogers, K Sanders, E Seeman, G Nicholson
In this population-based study, we evaluated the association between exposure to hormone therapy (HT), bone mineral density (BMD) and the prevalence of non-vertebral fractures. The study was set in a region located in southeastern Australia where complete fracture ascertainment was determined from radiological reports. Current HT use for at least 6 months was ascertained in women with non-vertebral fractures [median age 70.9 years; inter-quartile range (IQR) 66.5–75.9 years] and randomly selected controls (median age 70.8 years; IQR 65.2–75.0 years). Current HT use was documented in 20 of 262 cases and 49 of 364 controls. The odds ratio (OR) for non-vertebral fracture associated with HT use was 0.53 (95% CI 0.31–0.92). HT use was associated with 2.6–7.5% higher BMD at axial and appendicular sites. HT use is associated with a halving of risk for non-vertebral fractures and higher BMD.

History

Journal

Osteoporosis International

Volume

15

Issue

6

Pagination

434 - 438

Publisher

Springer U. K.

Location

Surrey, England

ISSN

0937-941X

eISSN

1433-2965

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2004, International Osteoporosis Foundation and National Osteoporosis Foundation