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Human major infections: Tuberculosis, treponematoses, leprosy—A paleopathological perspective of their evolution

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posted on 25.02.2021, 00:00 authored by Maciej Henneberg, Kara Holloway-Kew, Teghan Lucas
The key to evolution is reproduction. Pathogens can either kill the human host or can invade the host without causing death, thus ensuring their own survival, reproduction and spread. Tuberculosis, treponematoses and leprosy are widespread chronic infectious diseases whereby the host is not immediately killed. These diseases are examples of the co-evolution of host and pathogen. They can be well studied as the paleopathological record is extensive, spanning over 200 human generations. The paleopathology of each disease has been well documented in the form of published synthetic analyses recording each known case and case frequencies in the samples they were derived from. Here the data from these synthetic analyses were re-analysed to show changes in the prevalence of each disease over time. A total of 69,379 skeletons are included in this study. There was ultimately a decline in the prevalence of each disease over time, this decline was statistically significant (Chi-squared, p<0.001). A trend may start with the increase in the disease’s prevalence before the prevalence declines, in tuberculosis the decline is monotonic. Increase in skeletal changes resulting from the respective diseases appears in the initial period of host-disease contact, followed by a decline resulting from co-adaptation that is mutually beneficial for the disease (spread and maintenance of pathogen) and host (less pathological reactions to the infection). Eventually either the host may become immune or tolerant, or the pathogen tends to be commensalic rather than parasitic.

History

Journal

PLoS One

Volume

16

Issue

2

Article number

e0243687

Pagination

1 - 16

Publisher

Public Library of Science (PLoS)

Location

San Francisco, Calif.

ISSN

1932-6203

eISSN

1932-6203

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

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