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Identification and genetic determination of an early life risk disposition for depressive disorder : atypical stress-related behaviour in early childhood
journal contribution
posted on 2011-03-01, 00:00 authored by J van Eekelen, Craig OlssonCraig Olsson, J Ellis, W Ang, Delyse HutchinsonDelyse Hutchinson, S Zubrick, C PennellProgress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders. We argue that greater use of early detectable intermediate traits (endophenotypes) with the highest likely aetiological significance to depression, rather than complex clinical phenotypes, would be advantageous. Longitudinal data from the Western Australian Pregnancy Cohort (Raine) Study were used to identify an early life behavioural endophenotype for atypical hypothalamic-pituitaryadrenocortical function in adolescence, a neurobiological indicator of anxiety and depression. A set of descriptors representing rigid and reactive behaviour at age 1 year discriminated those in the top 20% of the free salivary cortisol exposure at age 17 years. Genetic association analysis revealed a male-sensitive effect to variation in three specific single nucleotide polymorphisms within selected genes underpinning the overall stress response. Furthermore, support for a polygenic effect on stress-related behaviour in childhood is presented.
History
Journal
Australian journal of psychologyVolume
63Issue
1Pagination
6 - 17Publisher
John Wiley & Sons Ltd.Location
Oxford, U. K.Publisher DOI
ISSN
0004-9530eISSN
1742-9536Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2011, The Australian Psychological SocietyUsage metrics
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