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Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle

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Over the course of ageing there is a natural and progressive loss of skeletal muscle mass. The onset and progression of age-related muscle wasting is associated with an attenuated activation of Akt-mTOR signalling and muscle protein synthesis in response to anabolic stimuli such as resistance exercise. MicroRNAs (miRNAs) are novel and important post-transcriptional regulators of numerous cellular processes. The role of miRNAs in the regulation of muscle protein synthesis following resistance exercise is poorly understood. This study investigated the changes in skeletal muscle miRNA expression following an acute bout of resistance exercise in young and old subjects with a focus on the miRNA species predicted to target Akt-mTOR signalling.

History

Journal

PLoS One

Volume

9

Issue

12

Article number

e114009

Pagination

1 - 25

Publisher

PLoS

Location

San Francisco, Calif.

eISSN

1932-6203

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2014, PLoS