zacharewicz-identificationof-2014.pdf (1.64 MB)
Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle
journal contributionposted on 2014-01-01, 00:00 authored by Evelyn Zacharewicz, Paul Della GattaPaul Della Gatta, John Reynolds, Andrew GarnhamAndrew Garnham, Tamsyn CrowleyTamsyn Crowley, Aaron RussellAaron Russell, Severine LamonSeverine Lamon
Over the course of ageing there is a natural and progressive loss of skeletal muscle mass. The onset and progression of age-related muscle wasting is associated with an attenuated activation of Akt-mTOR signalling and muscle protein synthesis in response to anabolic stimuli such as resistance exercise. MicroRNAs (miRNAs) are novel and important post-transcriptional regulators of numerous cellular processes. The role of miRNAs in the regulation of muscle protein synthesis following resistance exercise is poorly understood. This study investigated the changes in skeletal muscle miRNA expression following an acute bout of resistance exercise in young and old subjects with a focus on the miRNA species predicted to target Akt-mTOR signalling.
Pagination1 - 25
LocationSan Francisco, Calif.
Publication classificationC Journal article; C1 Refereed article in a scholarly journal
Copyright notice2014, PLoS
CategoriesNo categories selected