Deakin University
Browse
lotfaliany-impactofhypertension-2017.pdf (1.05 MB)

Impact Of Hypertension versus Diabetes on Cardiovascular and All-cause Mortality in Iranian Older Adults: Results of 14 Years of Follow-up

Download (1.05 MB)
Version 3 2024-06-18, 23:38
Version 2 2024-06-04, 13:41
Version 1 2020-10-15, 18:32
journal contribution
posted on 2024-06-18, 23:38 authored by N Zafari, S Asgari, Mojtaba Lotfaliany Abrand AbadiMojtaba Lotfaliany Abrand Abadi, A Hadaegh, F Azizi, F Hadaegh
To evaluate the joint effect of hypertension (HTN) and diabetes (DM) on coronary heart disease (CHD), and stroke event, all-cause, and cardiovascular disease (CVD) mortality in Middle Eastern older adults, 2747 people (1436 women) aged ≥ 50 years, free of CVD at baseline, were categorized into four groups (HTN−/DM−, HTN+/DM−, HTN−/DM+, HTN+/DM+). Multivariate Cox proportional hazard models were run for different outcomes. To compare the impact of HTN versus DM, HTN+/DM− was considered as reference. In a median of 13.9 years, incidence rate of CHD, and stroke event, all-cause and CVD mortality in total population were 19.0, 4.7, 13.5, and 6.4 per 1000 person-years, respectively. The multivariate sex-adjusted hazard ratios (HRs) of HTN−/DM+ for CHD, stroke, all-cause mortality and CVD mortality were 1.19 (confidence interval (CI): 0.9–1.57), 1.07 (CI: 0.63–1.82), 1.62 (CI: 1.2–2.18), and 1.28 (CI: 0.83–1.97); the corresponding HRs for HTN+/DM+ were 1.96 (CI: 1.57–2.46), 1.66 (CI: 1.1–2.52), 2.32 (CI: 1.8–2.98), and 2.6 (CI: 1.85–3.65) respectively. The associations between HTN/DM status with stroke incidence and all-cause mortality were stronger among men than in women (P for interaction <0.05). Compared to HTN+/DM−, HTN−/DM+ increases all-cause mortality by 62%, however, they are not considerably different regarding CHD, stroke incidence and CVD mortality.

History

Journal

Scientific Reports

Volume

7

Article number

ARTN 14220

Pagination

1 - 8

Location

England

Open access

  • Yes

ISSN

2045-2322

eISSN

2045-2322

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2017, The Author(s)

Issue

1

Publisher

NATURE PORTFOLIO

Usage metrics

    Research Publications

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC