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Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men

journal contribution
posted on 2011-03-01, 00:00 authored by M Trenerry, Paul Della GattaPaul Della Gatta, Amy Larsen, Andrew GarnhamAndrew Garnham, David Cameron-Smith
The JAK/STAT signaling pathway is essential for myogenic regeneration and is regulated by a diverse range of ligands, including interleukin-6 (IL-6) and platelet-derived growth factor-BB (PDGF-BB). Our aim was to evaluate the responsiveness of IL-6 and PDGF-BB to intense exercise, along with STAT3 activation, before and after 12 weeks of resistance training. In young men, IL-6 and PDGF-BB protein concentrations were quantified in biopsied muscle and increased at 3 h post-exercise (17.5-fold and 3-fold, respectively). The response was unaltered by 12 weeks of training. Similarly, STAT3 phosphorylation was elevated post-exercise (12.5-fold), irrespective of training status, as was the expression of downstream targets c-MYC (8-fold), c-FOS (4.5-fold), and SOCS3 (2.3-fold). Thus, intense exercise transiently increases IL-6 and PDGF-BB proteins, and STAT3 phosphorylation is increased. These responses are preserved after intense exercise. This suggests they are not modified by training and may be an essential component of the adaptive responses to intense exercise.

History

Journal

Muscle & nerve

Volume

43

Issue

3

Pagination

385 - 392

Publisher

John Wiley & Sons, Inc.

Location

New York, N. Y.

ISSN

0148-639X

eISSN

1097-4598

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2010, Wiley Periodicals