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Impaired Maturation of Cognitive Control in Adolescents Who Develop Major Depressive Disorder

Version 2 2024-06-05, 02:33
Version 1 2019-06-27, 14:10
journal contribution
posted on 2024-06-05, 02:33 authored by Nandi VijayakumarNandi Vijayakumar, S Whittle, M Yücel, ML Byrne, O Schwartz, JG Simmons, NB Allen
© 2015, Copyright © Taylor & Francis Group, LLC. This study examined whether development of two forms of cognitive control (proactive and reactive) between early and midadolescence was associated with the onset of major depressive disorder (MDD) during the same period and if it prospectively predicted MDD onset between mid- and late adolescence. Adolescents (N = 165) completed 3 waves of assessments, at 12 (T1), 16 (T2), and 18 (T3) years of age. Diagnostic interviews were conducted at each time point to identify three groups of adolescents: “early MDD,” those who developed MDD between early (T1) and mid- (T2) adolescence (n = 23); “late MDD,” those who developed MDD between mid- (T2) and late (T3) adolescence (n = 20); and “controls,” those who did not develop MDD (n = 122). A modified Stroop task was completed at T1 and T2 to examine development of proactive and reactive cognitive control. Adolescents with early MDD exhibited significant declines in reactive control, as well as a trend level decline for proactive control, during this period compared to controls. No significant differences in reactive or proactive control were identified in adolescents with late MDD compared to controls, but they did exhibit significant improvements in proactive control compared to those with early MDD. These findings suggest that normative maturation of reactive, and possibly proactive, cognitive control abilities are impaired in adolescents who develop MDD between early and midadolescence. This has implications for understanding the mechanisms underlying certain forms of behavioral dysregulation that are commonly seen in MDD.

History

Journal

Journal of Clinical Child and Adolescent Psychology

Volume

45

Pagination

31-43

Location

England

ISSN

1537-4416

eISSN

1537-4424

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2015, Taylor & Francis Group

Issue

1

Publisher

ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD