caeyenberghs-impairedrichclub-2018.pdf (795.04 kB)
Impaired rich club and increased local connectivity in children with traumatic brain injury: Local support for the rich?
journal contribution
posted on 2018-07-01, 00:00 authored by H Verhelst, C Vander Linden, T De Pauw, G Vingerhoets, Karen CaeyenberghsKaren Caeyenberghs© 2018 Wiley Periodicals, Inc. Recent evidence has shown the presence of a “rich club” in the brain, which constitutes a core network of highly interconnected and spatially distributed brain regions, important for high-order cognitive processes. This study aimed to map the rich club organization in 17 young patients with moderate to severe TBI (15.71 ± 1.75 years) in the chronic stage of recovery and 17 age- and gender-matched controls. Probabilistic tractography was performed on diffusion weighted imaging data to construct the edges of the structural connectomes using number of streamlines as edge weight. In addition, the whole-brain network was divided into a rich club network, a local network and a feeder network connecting the latter two. Functional outcome was measured with a parent questionnaire for executive functioning. Our results revealed a significantly decreased rich club organization (p values <.05) and impaired executive functioning (p <.001) in young patients with TBI compared with controls. Specifically, we observed reduced density values in all three subnetworks (p values <.005) and a reduced mean strength in the rich club network (p =.013) together with an increased mean strength in the local network (p =.002) in patients with TBI. This study provides new insights into the nature of TBI-induced brain network alterations and supports the hypothesis that the local subnetwork tries to compensate for the biologically costly subnetwork of rich club nodes after TBI.
History
Journal
Human Brain MappingVolume
39Issue
7Pagination
2800 - 2811Publisher
WileyLocation
London, Eng.Publisher DOI
Link to full text
ISSN
1065-9471eISSN
1097-0193Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
diffusion-weighted imaginggraph theoryrich clubstructural connectivitytraumatic brain injuryScience & TechnologyLife Sciences & BiomedicineNeurosciencesNeuroimagingRadiology, Nuclear Medicine & Medical ImagingNeurosciences & NeurologySTATE FUNCTIONAL CONNECTIVITYDIFFUSION MRISTRUCTURAL CONNECTOMESMALL-WORLDORGANIZATIONTRACTOGRAPHYPLASTICITYNETWORKSDISORDERSYSTEM
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC