File(s) under permanent embargo

In-vitro evaluation of marine derived fungi against Cutibacterium acnes

journal contribution
posted on 2018-02-01, 00:00 authored by Shivankar Agrawal, Alok AdholeyaAlok Adholeya, Colin BarrowColin Barrow, S K Deshmukh
Cutibacterium acnes (or Propionibacterium acnes) is the main target for the prevention and medical treatment of acne vulgaris. The aim of this study was to evaluate the in vitro anti-C. acnes and anti-S. epidermidis properties of some marine fungi isolated from different Indian marine environments. Seventy fungal isolates were obtained from samples collected from the west coasts and Andaman Island, India. Methanol extracts of 35 isolates were screened for their antibacterial properties and 5 out of the 35 isolates displayed significant inhibition as compared with tetracycline. DNA was successfully extracted from these five fungal isolates and phylogenetic analysis was performed. The methanol extracts possessed antibacterial activity against C. acnes and S. epidermidis with MIC values ranged from 0.8 mg/mL to 1 mg/mL. SEM analysis revealed that the extract induces deleterious morphological changes in the bacterial cell membrane. This study has identified some fungi extracts with significant antibacterial activity. The extracts may have potential for development as an antibacterial agent in the treatment of acne vulgaris.

History

Journal

Anaerobe

Volume

49

Pagination

5 - 13

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

1075-9964

eISSN

1095-8274

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Elsevier