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In vitro behavior of human osteoblast-like cells (SaOS2) cultured on surface modified titanium and titanium–zirconium alloy
journal contribution
posted on 2011-10-10, 00:00 authored by Xiaobo Chen, Yuncang Li, Peter HodgsonPeter Hodgson, Cui'E WenIn this study, titanium (Ti) and titanium-zirconium (TiZr) alloy samples fabricated through powder metallurgy were surface modified by alkali-heat treatment and calcium (Ca)-ion-deposition. The alteration of the surface morphology and the chemistry of the Ti and TiZr after surface modification were examined. The bioactivity of the Ti and TiZr alloys after the surface modification was demonstrated. Subsequently, the cytocompatibility of the surface modified Ti and TiZr was evaluated via in vitro cell culture using human osteoblast-like cells (SaOS2). The cellular attachment, adhesion and proliferation after cell culture for 14 days were characterized by scanning electron microscopy (SEM) and MTT assay. The relationship between surface morphology and chemical composition of the surface modified Ti and TiZr and cellular responses was investigated. Results indicated that the surface-modified Ti and TiZr alloys exhibited excellent in vitro cytocompatibility together with satisfactory bioactivity. Since osteoblast adhesion and proliferation are essential prerequisites for a successful implant in vivo, these results provide evidence that Ti and TiZr alloys after appropriate surface modification are promising biomaterials for hard tissue replacement.
History
Journal
Materials science and engineering : CVolume
31Issue
7Pagination
1545 - 1552Publisher
Elsevier SALocation
Lausanne, SwitzerlandISSN
0928-4931eISSN
1873-0191Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2011, Elsevier B.V.Usage metrics
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No categories selectedKeywords
apatitein vitro cytocompatibilitymodified simulated body fluid (m-SBF)surface modificationtitanium (Ti)titanium-zirconium (TiZr) alloyScience & TechnologyTechnologyMaterials Science, BiomaterialsMaterials ScienceAPATITE-INDUCING ABILITYSIMULATED BODY-FLUIDSBIOMEDICAL APPLICATIONSPOROUS TITANIUMHEAT-TREATMENTRESPONSESADHESIONMETALSGROWTHENERGY
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