In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: Formation of reactive iminium and quinone type metabolites

Zhang, ZP; Chen, Q; Li, Y; Doss, GA; Dean, Belinda; Ngui, JS; Elipe, MS; Kim, S; Wu, JY; DiNinno, F; Hammond, ML; Stearns, RA; Evans, DC; Baillie, TA; Tang, W

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: Formation of reactive iminium and quinone type metabolites

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posted on 2025-04-10, 01:29 authored by ZP Zhang, Q Chen, Y Li, GA Doss, Belinda DeanBelinda Dean, JS Ngui, MS Elipe, S Kim, JY Wu, F DiNinno, ML Hammond, RA Stearns, DC Evans, TA Baillie, W Tang

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: Formation of reactive iminium and quinone type metabolites

History

Journal

CHEMICAL RESEARCH IN TOXICOLOGY

Volume

18

Pagination

675-685

Location

United States

Publisher DOI

https://doi.org/10.1021/tx0496789

ISSN

0893-228X

eISSN

1520-5010

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

4

Publisher

AMER CHEMICAL SOC

Publication URL

https://doi.org/10.1021/tx0496789

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Keywords

Science & Technology Life Sciences & Biomedicine Physical Sciences Chemistry, Medicinal Chemistry, Multidisciplinary Toxicology Pharmacology & Pharmacy Chemistry MULTIFUNCTIONAL MEDICINES DRUG DISCOVERY LIGANDS TAMOXIFEN MECHANISM ADDUCTS SERAMS ENZYME IDENTIFICATION ANTIESTROGENS

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: Formation of reactive iminium and quinone type metabolites

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