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Increased left hemisphere impairment in High- functioning autism: A tract based spatial statistics study.

Version 2 2024-06-04, 03:34
Version 1 2023-10-26, 04:19
journal contribution
posted on 2024-06-04, 03:34 authored by T Perkins, Mark StokesMark Stokes, Jane McGillivrayJane McGillivray, Alexander MussapAlexander Mussap, IA Cox, JJ Maller, RG Bittar
There is evidence emerging from Diffusion Tensor Imaging (DTI) research that autism spectrum disorders (ASD) are associated with greater impairment in the left hemisphere. Although this has been quantified with volumetric region of interest analyses, it has yet to be tested with white matter integrity analysis. In the present study, tract based spatial statistics was used to contrast white matter integrity of 12 participants with high-functioning autism or Aspergers syndrome (HFA/AS) with 12 typically developing individuals. Fractional Anisotropy (FA) was examined, in addition to axial, radial and mean diffusivity (AD, RD and MD). In the left hemisphere, participants with HFA/AS demonstrated significantly reduced FA in predominantly thalamic and fronto-parietal pathways and increased RD. Symmetry analyses confirmed that in the HFA/AS group, WM disturbance was significantly greater in the left compared to right hemisphere. These findings contribute to a growing body of literature suggestive of reduced FA in ASD, and provide preliminary evidence for RD impairments in the left hemisphere. © 2014 Elsevier Ireland Ltd.

History

Journal

Psychiatry research: neuroimaging

Volume

224

Pagination

119-123

Location

Shannon, Ireland

ISSN

0925-4927

eISSN

1872-7506

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2014, Elsevier

Issue

2

Publisher

Elsevier