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Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic
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posted on 2022-11-30, 03:34 authored by Luba SominskyLuba Sominsky, A K Walker, L K Ong, R J Tynan, F R Walker, D M HodgsonNeonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour in adulthood. Our current aim was to examine whether neonatal LPS exposure is associated with changes in microglial activation, and whether these alterations correspond with alterations in behaviour. In adulthood, LPS-treated animals exhibited significantly increased anxiety-like behaviour and hippocampal microglial activation. The efficacy of the LPS challenge was confirmed by increased neonatal plasma corticosterone and tyrosine hydroxylase (TH) phosphorylation in the adrenal medulla. These findings suggest a neuroimmune pathway which may underpin the long-term behavioural and neuroendocrine changes following neonatal infection. © 2011 Elsevier B.V.
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Journal
Behavioural Brain ResearchVolume
226Pagination
351 - 356Publisher DOI
ISSN
0166-4328eISSN
1872-7549Publication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyLPSPostnatalAnxiety behaviourHPA axisTH phosphorylationMicroglial activationHippocampusANXIETY-LIKE BEHAVIORENDOTOXIN EXPOSUREANIMAL-MODELSLIFE ALTERSSTRESSLIPOPOLYSACCHARIDERESPONSESPHOSPHORYLATIONADULTHOOD
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