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Increased severity and spread of Mycobacterium ulcerans, Southeastern Australia

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Version 2 2024-06-03, 23:12
Version 1 2018-07-09, 11:09
journal contribution
posted on 2024-06-03, 23:12 authored by Alex YC Tai, Eugene AthanEugene Athan, N Deborah Friedman, Andrew HughesAndrew Hughes, Aaron Walton, Daniel P O'Brien
Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998-May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. A total of 20.4% of cases-patients had severe disease. Over time, there has been an increase in the number of cases managed per year and the proportion associated with severe disease. Risk factors associated with severe disease included age, time period (range of years of diagnosis), and location of lesions over a joint. We highlight the changing epidemiology and pathogenicity of M. ulcerans disease in Australia. Further research, including genomic studies of emergent strains with increased pathogenicity, are urgently needed to improve the understanding of disease to facilitate implementation of effective public health measures to halt its spread.

History

Journal

Emerging infectious diseases

Volume

24

Pagination

58-64

Location

Atlanta, Ga.

ISSN

1080-6040

eISSN

1080-6059

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

This work is in the Public Domain and has no copyright restriction

Issue

1

Publisher

Centers for Disease Control and Prevention