Deakin University
Browse
guernier-individualand-2018.pdf (304.87 kB)

Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study

Download (304.87 kB)
Version 2 2024-06-13, 11:34
Version 1 2018-07-10, 09:59
journal contribution
posted on 2024-06-13, 11:34 authored by A Fred, A Fianu, M Béral, V Guernier, D Sissoko, M Méchain, A Michault, V Boisson, B-A Gaüzère, F Favier, D Malvy, P Gérardin, SEROCHIK group
The purpose of the study was to weigh the community burden of chikungunya determinants on Reunion island. Risk factors were investigated within a subset of 2101 adult persons from a population-based cross-sectional serosurvey, using Poisson regression models for dichotomous outcomes. Design-based risk ratios and population attributable fractions (PAF) were generated distinguishing individual and contextual (i.e. that affect individuals collectively) determinants. The disease burden attributable to contextual determinants was twice that of individual determinants (overall PAF value 89.5% vs. 44.1%). In a model regrouping both categories of determinants, the independent risk factors were by decreasing PAF values: an interaction term between the reporting of a chikungunya history in the neighbourhood and individual house (PAF 45.9%), a maximal temperature of the month preceding the infection higher than 28.5 °C (PAF 25.7%), a socio-economically disadvantaged neighbourhood (PAF 19.0%), altitude of dwelling (PAF 13.1%), cumulated rainfalls of the month preceding the infection higher than 65 mm (PAF 12.6%), occupational inactivity (PAF 11.6%), poor knowledge on chikungunya transmission (PAF 7.3%) and obesity/overweight (PAF 5.2%). Taken together, these covariates and their underlying causative factors uncovered 80.8% of chikungunya at population level. Our findings lend support to a major role of contextual risk factors in chikungunya virus outbreaks.

History

Journal

Epidemiology and infection

Volume

146

Pagination

1056-1064

Location

Cambridge, England

Open access

  • Yes

eISSN

1469-4409

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, Cambridge University Press

Issue

8

Publisher

Cambridge University Press

Usage metrics

    Research Publications

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC