Deakin University
Browse

File(s) under permanent embargo

Indomethacin and protein binding of methotrexate

journal contribution
posted on 1992-07-01, 00:00 authored by R Raveendran, W Heybroek, M Caulfield, Mary LawsonMary Lawson, S M Abrams, P F Wrigley, M Slevin, P Turner
Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by indomethacin from albumin might explain this interaction. To investigate the possible interaction an in-vitro protein-binding displacement study was carried out in 17 normal volunteers and in two groups of eight cancer patients. One group of patients had active disease and the other was in complete clinical remission. Serum samples were obtained and protein levels estimated. The protein binding of methotrexate was measured alone and with indomethacin using equilibrium dialysis. Statistical analysis of results suggested that the binding of methotrexate is not influenced by indomethacin, confirming that methotrexate is not displaced by indomethacin.

History

Journal

Hum Exp Toxicol

Volume

11

Issue

4

Pagination

291 - 293

Publisher

Sage Publications

Location

England

ISSN

0960-3271

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

Macmillan Press, 1992

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC