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Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery.

Version 2 2024-06-06, 11:36
Version 1 2016-09-09, 14:41
journal contribution
posted on 2024-06-06, 11:36 authored by GT Vladisavljević, N Khalid, MA Neves, T Kuroiwa, M Nakajima, K Uemura, S Ichikawa, I Kobayashi
Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery.

History

Journal

Advanced drug delivery reviews

Volume

65

Pagination

1626-1663

Location

Amsterdam, The Netherlands

ISSN

1872-8294

eISSN

1872-8294

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2013, Elsevier BV

Issue

11-12

Publisher

Elsevier