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Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery.
journal contributionposted on 2013-11-15, 00:00 authored by G T Vladisavljević, Nauman Khalid, M A Neves, T Kuroiwa, M Nakajima, K Uemura, S Ichikawa, I Kobayashi
Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery.
JournalAdvanced drug delivery reviews
Pagination1626 - 1663
LocationAmsterdam, The Netherlands
Publication classificationC Journal article; C1.1 Refereed article in a scholarly journal
Copyright notice2013, Elsevier BV
CategoriesNo categories selected
microfluidicsdevice fabricationunit operationscale-upmonodisperse dropletsparallel flowfunctional materialsbiological processingScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacySINGLE-CELL ANALYSISIN-WATER EMULSIONSMONODISPERSE DOUBLE EMULSIONSPOINT-OF-CARECONTROLLABLE MICROFLUIDIC PRODUCTIONCHITOSAN-BASED NANOPARTICLESONE-STEP FORMATIONDROPLET FORMATIONMICROCHANNEL EMULSIFICATIONHIGH-THROUGHPUT