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Inflammatory biomarkers in overweight and obese Iranian women are associated with polyphenol intake
journal contribution
posted on 2023-05-26, 06:34 authored by F Shiraseb, D Hosseininasab, S Noori, Sara EbrahimiSara Ebrahimi, F Asjodi, R Ghaffarian-Ensaf, RA Carnauba, K MirzaeiBackground: The evidence shows that obesity is associated with chronic inflammation in obese subjects. Polyphenols are a complex group of plant secondary metabolites that may play a role in reducing the risk of obesity and obesity-related diseases. Given the scarcity of evidence on the association between inflammatory markers and dietary polyphenols intake in overweight/obese Iranian women, the current study aims to investigate this link. Method: The present cross-sectional study was conducted on 391 overweight and obese Iranian women aged 18–48 years (body mass index (BMI) ≥ 25 kg/m2). A 147-item food frequency questionnaire (FFQ) was used to assess dietary intake, as well as anthropometric indices including weight, height, waist circumference (WC), and hip circumference (HC) and biochemistry parameters including triglyceride (TG), total cholesterol (Chole), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), galactin-3 (Gal-3), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta (TGF-β), interleukin-1 beta (IL_1β), plasminogen activator inhibitor-1 (PA-I), serum leptin concentrations, and C-reactive protein of high sensitivity (hs-CRP) in all participants. The inflammatory markers were assessed using the enzyme-linked immunosorbent assay (ELISA). Result: The findings revealed a significant negative association between flavonoids intake and MCP-1 (P = 0.024), lignans intake and MCP-1 (P = 0.017), and Gal-3 (P = 0.032). These significant associations were observed between other polyphenols intake and IL_1β (P = 0.014). There was also a significant positive association between other polyphenol intake and TGF-β (P = 0.008) and between phenolic acid intake and TGF-β (P = 0.014). Conclusion: Our findings suggest that a high polyphenol intake may help individuals to reduce systemic inflammation. Further large studies involving participants of different ages and genders are highly warranted.
History
Journal
Journal of Health, Population and NutritionVolume
42Article number
39Pagination
39-Location
BangladeshPublisher DOI
ISSN
1606-0997eISSN
2072-1315Language
enIssue
1Publisher
Springer Science and Business Media LLCUsage metrics
Keywords
C-reactive proteinInflammationObesityPolyphenolsTGF-betaFemaleHumansMaleOverweightIranCross-Sectional StudiesBiomarkersBody Mass IndexCholesterolTransforming Growth Factor betapolyphenolsinflammationobesityComplementary and Integrative HealthPreventionClinical ResearchNutritionStrokeOral and gastrointestinalCancerCardiovascularMetabolic and endocrine