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Inflammatory versus anti-inflammatory profiles in major depressive disorders—the role of il-17, il-21, il-23, il-35 and foxp3

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Version 2 2024-06-05, 05:06
Version 1 2021-01-29, 08:16
journal contribution
posted on 2024-06-19, 01:12 authored by M Gałecka, K Bliźniewska-Kowalska, A Orzechowska, J Szemraj, M Maes, Michael BerkMichael Berk, KP Su, P Gałecki
Background: The authors of this research study intended to verify whether there are any changes in gene expression in depressed patients without coexisting inflammatory diseases for selected immune-inflammatory factors that are particularly important in autoimmune disease pathogenesis (IL-17, IL-21, IL-23, IL-35, Foxp3). Methods: The study was carried out on a group of 190 patients with depression and 100 healthy volunteers. The severity of depressive symptoms was assessed using the Hamilton Depression Scale. RT-PCR was used to evaluate mRNA expression and ELISA was used to measure protein expression of these genes. Results: The level of gene expression for IL-17, IL-21, IL-23, and IL-35 was substantially higher in the group of patients with depression compared to the control group. The mean mRNA expression of Foxp3 was considerably reduced in patients suffering from depressive disorders. There was a statistically significant correlation between the number of hospitalizations and the expression of specific inflammatory factors. Conclusions: Expression of specific inflammatory genes may be a factor in the etiopathogenesis of depressive disorders. The duration of the disease seems to be more important for the expression of the genes in question than the severity of depression. These cytokines may affect the metabolism of neurotransmitters and neuroendocrine functions in the brain as well as be a marker and a new potential therapeutic target for recurrent depressive disorders.

History

Journal

Journal of Personalized Medicine

Volume

11

Article number

ARTN 66

Pagination

1-14

Location

Switzerland

Open access

  • Yes

ISSN

2075-4426

eISSN

2075-4426

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

2

Publisher

MDPI