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Innate Immune Activation and Circulating Inflammatory Markers in Preschool Children

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journal contribution
posted on 2022-02-08, 00:00 authored by F Collier, C Chau, T Mansell, K Faye-Chauhan, Peter VuillerminPeter Vuillermin, A L Ponsonby, R Saffery, M L K Tang, M O’Hely, J Carlin, Lawrence GrayLawrence Gray, S Bekkering, D Burgner
Early childhood is characterised by repeated infectious exposures that result in inflammatory responses by the innate immune system. In addition, this inflammatory response to infection is thought to contribute to the epidemiological evidence linking childhood infection and adult non-communicable diseases. Consequently, the relationship between innate immune responses and inflammation during early life may inform prevention of NCDs later in life. In adults, non-genetic host factors such as age, sex, and obesity, strongly impact cytokine production and circulating mediators, but data in children are lacking. Here, we assessed cytokine responses and inflammatory markers in a population of healthy preschool children (mean age 4.2 years). We studied associations between cytokines, plasma inflammatory markers and non-genetic host factors, such as sex, age, adiposity, season, and immune cell composition. Similar to adults, boys had a higher inflammatory response than girls, with IL-12p70 and IL-10 upregulated following TLR stimulation. Adiposity and winter season were associated with increased circulating inflammatory markers but not cytokine production. The inflammatory markers GlycA and hsCRP were positively associated with production of a number of cytokines and may therefore reflect innate immune function and inflammatory potential. This dataset will be informative for future prospective studies relating immune parameters to preclinical childhood NCD phenotypes.

History

Journal

Frontiers in Immunology

Volume

12

Article number

ARTN 830049

Pagination

1 - 8

Publisher

Frontiers Media

Location

Lausanne, Switzerland

ISSN

1664-3224

eISSN

1664-3224

Language

English

Publication classification

C1 Refereed article in a scholarly journal