Deakin University
Browse

File(s) not publicly available

Integrated aeroelastic vibrator for fluid mixing in open microwells

journal contribution
posted on 2022-09-28, 05:27 authored by H M Xia, X Jin, Y Y Zhang, J W Wu, Jun ZhangJun Zhang, Z P Wang
Fluid mixing in micro-wells/chambers is required in a variety of biological and biochemical processes. However, mixing fluids of small volumes is usually difficult due to increased viscous effects. In this study, we propose a new method for mixing enhancement in microliter-scale open wells. A thin elastic diaphragm is used to seal the bottom of the mixing microwell, underneath which an air chamber connects an aeroelastic vibrator. Driven by an air flow, the vibrator produces self-excited vibrations and causes pressure oscillations in the air chamber. Then the elastic diaphragm is actuated to mix the fluids in the microwell. Two designs that respectively have one single well and 2 × 2 wells were prototyped. Testing results show that for liquids with a volume ranging from 10-60 μl and viscosity ranging from 1-5 cP, complete mixing can be obtained within 5-20 s. Furthermore, the device is operable with an air micropump, and hence facilitating the miniaturization and integration of lab-on-a-chip and microbioreactor systems.

History

Journal

Journal of Micromechanics and Microengineering

Volume

28

Issue

1

ISSN

0960-1317

eISSN

1361-6439