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Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment

journal contribution
posted on 03.10.2015, 00:00 authored by S J Street, N Parletta, Catherine MilteCatherine Milte, K Sullivan, A P Hills, J Buckley, P Howe
Objectives: To evaluate relationships between self-reported physical activity, proportions of long-chain omega-3
polyunsaturated fatty acids (LCn3) in erythrocyte content (percentage of total fatty acids) and risk of mild cognitive
impairment (MCI) in older adults.
Method: A cross-sectional study was conducted. Community-dwelling male and female (n D 84) participants over the age
of 65 years with and without MCI were tested for erythrocyte proportions of the LCn3s eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA). Physical activity was measured using a validated questionnaire.
Results: The interaction between erythrocyte EPA, but not DHA, and increased physical activity was associated with
increased odds of a non-MCI classification.
Conclusion: An interaction between physical activity and erythrocyte EPA content (percentage of fatty acids) significantly
predicted MCI status in older adults. Randomised control trials are needed to examine the potential for supplementation
with EPA in combination with increased physical activity to mitigate the risk of MCI in ageing adults.

History

Journal

Aging & mental health

Volume

19

Issue

10

Pagination

885 - 891

Publisher

Routledge

Location

Abingdon, Eng.

ISSN

1360-7863

eISSN

1364-6915

Language

eng

Notes

peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=camh20

Publication classification

C Journal article; C1.1 Refereed article in a scholarly journal

Copyright notice

2014, Taylor & Francis