Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment
Version 2 2024-06-03, 20:51Version 2 2024-06-03, 20:51
Version 1 2016-12-05, 14:44Version 1 2016-12-05, 14:44
journal contribution
posted on 2024-06-03, 20:51authored bySJ Street, N Parletta, Catherine MilteCatherine Milte, K Sullivan, AP Hills, J Buckley, P Howe
Objectives: To evaluate relationships between self-reported physical activity, proportions of long-chain omega-3
polyunsaturated fatty acids (LCn3) in erythrocyte content (percentage of total fatty acids) and risk of mild cognitive
impairment (MCI) in older adults.
Method: A cross-sectional study was conducted. Community-dwelling male and female (n D 84) participants over the age
of 65 years with and without MCI were tested for erythrocyte proportions of the LCn3s eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA). Physical activity was measured using a validated questionnaire.
Results: The interaction between erythrocyte EPA, but not DHA, and increased physical activity was associated with
increased odds of a non-MCI classification.
Conclusion: An interaction between physical activity and erythrocyte EPA content (percentage of fatty acids) significantly
predicted MCI status in older adults. Randomised control trials are needed to examine the potential for supplementation
with EPA in combination with increased physical activity to mitigate the risk of MCI in ageing adults.
History
Journal
Aging & mental health
Volume
19
Pagination
885-891
Location
Abingdon, Eng.
ISSN
1360-7863
eISSN
1364-6915
Language
eng
Notes
peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope.
aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=camh20
Publication classification
C Journal article, C1.1 Refereed article in a scholarly journal