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Interactions between pro-inflammatory cytokines and statins on depression in patients with acute coronary syndrome

Version 2 2024-05-30, 15:24
Version 1 2017-07-26, 16:24
journal contribution
posted on 2024-05-30, 15:24 authored by SW Kim, HJ Kang, KY Bae, IS Shin, YJ Hong, YK Ahn, MH Jeong, Michael BerkMichael Berk, JS Yoon, JM Kim
Objective Pro-inflammatory cytokines are associated with the development of depression and statins exert anti-inflammatory and antidepressant effects. The present study aimed to investigate associations between interleukin (IL)-6 and IL-18 and depression in patients with acute coronary syndrome (ACS) and potential interactions between statin use and pro-inflammatory cytokines on depression in this population. Methods We used pooled datasets from 1-year follow-up data from a 24-week randomized double-blind placebo-controlled trial (RCT) of escitalopram for treatment of depressive disorder and data from a naturalistic, prospective, observational cohort study in patients with ACS. IL-6 and IL-18 levels were measured at baseline. Logistic regression models were used to investigate independent associations of IL-6/IL-18 levels with depressive disorder at baseline and at 1 year. We repeated all analyses by reference to statin use to determine whether any significant association emerged. Results Of the 969 participants, 378 (39.0%) had major or minor depression at baseline. Of 711 patients followed-up at 1 year, 183 (25.7%) had depression. Logistic regression analysis showed that higher IL-6 and IL-18 levels at baseline were significantly associated with baseline depression after adjusting for other variables (adjusted p-values = 0.005 and 0.001, respectively). IL-6 and IL-18 levels were also significantly higher in patients with depression at the 1-year follow-up after adjusting for other variables amongst those not taking statins (adjusted p-values = 0.040 and 0.004, respectively); but this was not the case in patients taking statins. Conclusion Levels of pro-inflammatory cytokines appear to predict development of depression after ACS and statins attenuate the effects of cytokines on depression.

History

Journal

Progress in neuro-psychopharmacology and biological psychiatry

Volume

80

Season

Part C

Pagination

250-254

Location

Amsterdam, The Netherlands

ISSN

0278-5846

eISSN

1878-4216

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2017, Elsevier Inc.

Issue

Pt C

Publisher

Elsevier