yang-interleukin-2014.pdf (1.25 MB)
Interleukin-10 inhibits bone resorption: a potential therapeutic strategy in periodontitis and other bone loss diseases
journal contribution
posted on 2014-01-01, 00:00 authored by Q Zhang, B Chen, F Yan, J Guo, X Zhu, S Ma, Wenrong YangWenrong YangPeriodontitis and other bone loss diseases, decreasing bone volume and strength, have a significant impact on millions of people with the risk of tooth loss and bone fracture. The integrity and strength of bone are maintained through the balance between bone resorption and bone formation by osteoclasts and osteoblasts, respectively, so the loss of bone results from the disruption of such balance due to increased resorption or/and decreased formation of bone. The goal of therapies for diseases of bone loss is to reduce bone loss, improve bone formation, and then keep healthy bone density. Current therapies have mostly relied on long-term medication, exercise, anti-inflammatory therapies, and changing of the life style. However there are some limitations for some patients in the effective treatments for bone loss diseases because of the complexity of bone loss. Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, and recent studies have indicated that IL-10 can contribute to the maintenance of bone mass through inhibition of osteoclastic bone resorption and regulation of osteoblastic bone formation. This paper will provide a brief overview of the role of IL-10 in bone loss diseases and discuss the possibility of IL-10 adoption in therapy of bone loss diseases therapy.
History
Journal
BioMed research internationalVolume
2014Article number
284836Pagination
1 - 6Publisher
Hindawi Publishing CorporationLocation
New York, NYPublisher DOI
ISSN
2314-6141eISSN
2314-6141Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, HindawiUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineBiotechnology & Applied MicrobiologyMedicine, Research & ExperimentalResearch & Experimental MedicineOSTEOCLAST DIFFERENTIATION FACTORGENE PROMOTER POLYMORPHISMSNECROSIS-FACTOR-ALPHARHEUMATOID-ARTHRITISKNOCKOUT MOUSEIL-10EXPRESSIONCELLSASSOCIATIONCYTOKINES
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