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Interventions to improve medication adherence in people with multiple chronic conditions: a systematic review
journal contribution
posted on 2008-07-01, 00:00 authored by A Williams, Elizabeth ManiasElizabeth Manias, R WalkerAIM: This paper is a report of a literature review to identify research involving interventions to improve medication adherence in people with multiple co-existing chronic conditions. Title. Interventions to improve medication adherence in people with multiple chronic conditions: a systematic review. Background. The importance of managing co-existing, chronic conditions in people of all ages is critical to prevent adverse health outcomes. DATA SOURCES: Databases, including Cumulative Index of Nursing and Allied Health Literature, Medline, PubMed and Web of Science were searched for the period January 1997-2007 using the combined keywords adherence, compliance, drug therapy, medication, clinical trial, randomized controlled trial, intervention, chronic condition, chronic disease, multiple morbidity and comorbidity. References of retrieved papers were also considered. METHODS: The inclusion criteria were: English language, oral medication adherence, self-administered medications, multiple prescribed medications for three or more chronic conditions and randomized controlled trials lasting at least 3 months. RESULTS: Studies examining medication adherence in people with multiple chronic conditions targeted people over 70 years of age, and were primarily focused on the management of polypharmacy and reducing healthcare costs. Adherence was measured using different tools and estimates of adherence, and interventions were predominantly delivered by pharmacists. The evidence for effective interventions to enhance medication adherence in multiple chronic conditions was weak, and psychosocial interventions were absent. CONCLUSION: Interventions that improve medication adherence for people with multiple chronic conditions are essential, given the increased prevalence of these conditions in people of all ages. Outcomes of improved adherence, such as disease control and quality of life, require investigation. Psychosocial interventions engaging people in medication self-management offer potential for improved patient outcomes in complex diseases.
History
Journal
Journal of Advanced NursingVolume
63Issue
2Pagination
132 - 143Publisher
Wiley-Blackwell PublishingLocation
Chichester, Eng.Publisher DOI
ISSN
0309-2402eISSN
1365-2648Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008, The Authors [2008, Blackwell Publishing]Usage metrics
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No categories selectedKeywords
AdherenceAgedAged, 80 and overChronic conditionChronic DiseaseComorbidityControlled Clinical Trials as TopicFemaleHumansInterventionsMaleMedicationNursingPatient CompliancePatient Education as TopicPolypharmacySelf AdministrationSystematic ReviewScience & TechnologyLife Sciences & BiomedicinePHARMACY-BASED PROVISIONSELF-MANAGEMENTPHARMACEUTICAL CAREELDERLY PATIENTSIMPACTDEPRESSIONOSTEOARTHRITISCOMORBIDITIESCHOLESTEROL
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