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Intrauterine growth retardation: clinical and experimental
journal contribution
posted on 1985-05-01, 00:00 authored by J S Robinson, J Falconer, Julie OwensJulie OwensIntrauterine growth retardation is a common and potentially hazardous problem for the fetus. Despite this, the obstetric factors associated with growth retardation have changed little in the last twenty years. Some of the other factors, the so-called behavioural factors should be amenable to correction through education or changing social circumstances. Experimental studies presented here support the clinical observations that the growth retarded fetus is often malnourished and/or hypoxaemic. Restriction of placental growth results in fetal growth failure and these fetuses are chronically hypoxaemic and hypoglycaemic. Furthermore the apparent margin of safety between the delivery to and consumption by the fetus is less for the small fetuses. We suggest that this reduction in supply results in the endocrine changes and that these in turn, modulate the pattern of fetal growth.
History
Journal
Acta paediatricaVolume
s319Pagination
135 - 142Publisher
WileyLocation
Chichester, Eng.Publisher DOI
ISSN
0300-8843Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1985, WileyUsage metrics
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No categories selectedKeywords
AnimalsEndorphinsEpinephrineFemaleFetal Growth RetardationFetal HeartFetusGlucoseHeart RateHumansHydrocortisoneMaternal-Fetal ExchangeNorepinephrineOxygen ConsumptionPregnancyProlactinRabbitsRatsReference ValuesSheepSomatomedinsThyroid HormonesThyroxineUterusbeta-EndorphinScience & TechnologyLife Sciences & BiomedicinePediatrics
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